Neuropsychiatric Drugs

Brand Name: Duzalta

Generic Name: Duloxetine HCl

Dosage Strength: 60mg

Manufacturer: PharmaEvo Pharmaceutical (Pvt) Ltd.

Packing: 14 Tablets

Description and Usage:

Duzalta (Duloxetine) 60mg Tablets are indicated for the treatment of various conditions, including:

• Major depressive disorder (MDD): A mood disorder characterized by persistent feelings of sadness, hopelessness, and loss of interest or pleasure in usual activities.
• Generalized anxiety disorder (GAD): A mental health condition characterized by excessive and uncontrollable worry about everyday events and activities.
• Fibromyalgia: A chronic pain disorder characterized by widespread musculoskeletal pain, fatigue, and tenderness in specific areas of the body.
• Chronic musculoskeletal pain: Chronic pain conditions such as chronic lower back pain, osteoarthritis, or chronic pain due to medical conditions.

Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) medication that works by increasing the levels of serotonin and norepinephrine in the brain. These neurotransmitters play a role in regulating mood, emotions, and pain perception. By inhibiting their reuptake, duloxetine helps to alleviate symptoms of depression, anxiety, and pain.

Brand Name: Paridopa

Generic Name: Levodopa + Carbidopa + Entacapone

Dosage Strength: 100mg Levodopa + 25mg Carbidopa + 200mg Entacapone

Manufacturer: PharmaEvo Pharmaceutical (Pvt) Ltd.

Packing: 30 Tablets

Description and Usage:

Paridopa (Levodopa+Carbidopa+Entacapone) tablets are indicated for the treatment of Parkinson’s disease in patients experiencing motor fluctuations. Levodopa is converted to dopamine in the brain, helping to replenish dopamine levels, while Carbidopa helps prevent the breakdown of levodopa before it reaches the brain. Entacapone prolongs the effects of levodopa by inhibiting the enzyme that breaks it down, thereby improving motor symptoms of Parkinson’s disease.

• Levodopa: Levodopa is a precursor of dopamine. In Parkinson’s disease, there is a deficiency of dopamine, a neurotransmitter involved in movement control. Levodopa crosses the blood-brain barrier and is converted into dopamine in the brain, thereby alleviating motor symptoms.
• Carbidopa: Carbidopa inhibits the peripheral decarboxylation of levodopa, ensuring more levodopa reaches the brain and reducing peripheral side effects.
• Entacapone: Entacapone inhibits the enzyme catechol-O-methyltransferase (COMT), which breaks down levodopa in the peripheral tissues. By inhibiting this enzyme, entacapone prolongs the effects of levodopa in the brain, thereby reducing motor fluctuations in Parkinson’s disease.

Brand Name: Xilica

Generic Name: Pregabalin

Dosage Strength: 25mg

Manufacturer: PharmaEvo Pharmaceutical (Pvt) Ltd.

Packing: 14 Capsules

Description and Usage:

Xilica is a brand name for pregabalin, which is a medication primarily used to treat neuropathic pain, epilepsy, fibromyalgia, and generalized anxiety disorder. Pregabalin is an anticonvulsant and anxiolytic medication that works by binding to calcium channels in the central nervous system, modulating the release of neurotransmitters such as glutamate, noradrenaline, and substance P.

• • Management of certain types of seizures
  • Treatment of neuropathic pain associated with diabetic neuropathy, postherpetic neuralgia, fibromyalgia
  • Management of generalized anxiety disorder (GAD)

Pregabalin binds to calcium channels in the central nervous system, modulating the release of neurotransmitters, particularly glutamate, norepinephrine, and substance P. This modulation helps in reducing neuronal excitability and alleviating pain and anxiety symptoms.

Brand Name: Agoviz

Generic Name: Agomelatine 

Dosage Strength: 25mg

Manufacturer: PharmaEvo Pharmaceutical (Pvt) Ltd.

Packing: 14 Tablets

Description and Usage:

Agoviz is a medication brand that typically contains the active ingredient Agomelatine in 25mg tablet form. Agomelatine is a novel antidepressant with a unique mechanism of action. Here’s a description of Agomelatine and its potential effects:

Agomelatine belongs to the class of medications known as melatonergic agonists and selective serotonin antagonists. It works by acting as an agonist at melatonin receptors (MT1 and MT2) and as an antagonist at serotonin 5-HT2C receptors.

Agomelatine’s antidepressant effects are believed to be mediated by its actions on melatonin and serotonin receptors in the brain. By enhancing melatonin receptor activity and blocking serotonin 5-HT2C receptors, agomelatine may help regulate circadian rhythms and improve mood.

Brand Name: Donecept

Generic Name: Donepezil Hydrochloride

Dosage Strength: 5mg

Manufacturer: Atco Pharmaceutical (Pvt) Ltd.

Packing: 10 Tablets

Description and Usage:

Donecept is a medication containing the active ingredient Donepezil Hydrochloride, typically available in 5mg tablets. Donepezil is a medication used in the treatment of Alzheimer’s disease, a progressive neurodegenerative disorder that affects memory, thinking, and behavior.

Donepezil belongs to a class of drugs known as cholinesterase inhibitors. It works by increasing the levels of a neurotransmitter called acetylcholine in the brain, which is involved in learning, memory, and other cognitive functions. By enhancing cholinergic activity, Donepezil helps improve cognitive function and may slow the progression of symptoms in people with Alzheimer’s disease.

Brand Name: ?

Generic Name: Tianeptine

Dosage Strength: 12.5mg

Manufacturer: Servier Pakistan

Packing: 30 Sugar Coated Tablets

Description and Usage:

Stablon is a brand name for the medication tianeptine. Tianeptine is an antidepressant agent used in the treatment of depression and related conditions.

Tianeptine is classified as a selective serotonin reuptake enhancer (SSRE) or a serotonin reuptake modulator (SRM).

It is primarily used for the treatment of major depressive disorder (depression).

The exact mechanism of action of tianeptine is not fully understood, but it is thought to modulate the reuptake of serotonin in the brain, leading to increased serotonin levels. Unlike traditional selective serotonin reuptake inhibitors (SSRIs), tianeptine has a unique pharmacological profile.

Brand Name: Paraxyl CR

Generic Name: Paroxetine HCl

Dosage Strength: 37.5mg

Manufacturer: CCL Pharmaceutical (Pvt) Ltd.

Packing: 30 Tablets

Description and Usage:

Paraxyl CR is a brand name for a specific formulation of the medication paroxetine hydrochloride (Paroxetine-HCl). The “CR” stands for “controlled release,” indicating that the medication is formulated to release the active ingredient gradually over an extended period. This can help maintain a steady concentration of the drug in the blood and potentially reduce side effects associated with rapid release.

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) used to treat conditions such as major depressive disorder, generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder.

The “CR” formulation means that the medication is designed to be released slowly over time, allowing for once-daily dosing and providing a sustained therapeutic effect.