Cabozanix 20 mg Capsules— Cabozantinib in Pakistan (Beacon Pharmaceuticals)

Description

Cabozanix 20 mg Capsules— Cabozantinib in Pakistan (Beacon Pharmaceuticals)

Product name: Cabozanix (cabozantinib) 20 mg capsules

Manufacturer: Beacon Pharmaceuticals (Cabozanix brand)

Pack size & price: 90 capsules per pack — PKR 212,500 (price provided by you; actual retail price may vary)

Mechanism of action of Cabozanix (cabozantinib):

Cabozanitinib is an oral tyrosine kinase inhibitor that targets multiple kinases involved in tumour growth, angiogenesis and metastasis — including MET, VEGFRs, AXL, RET, KIT, and others.

By blocking these signalling pathway,s the drug can slow tumour growth and reduce progression in several advanced cancers. cabometyx.com+1

Indications of Cabozanix (Cabozantinib):

Cabozanitinib is approved for several advanced malignancies (use and local approvals may vary; follow local regulatory labelling and oncology guidance):

• Advanced renal cell carcinoma (RCC) — as monotherapy for previously treated disease and, in some regions, in combination with nivolumab as first-line therapy. cabometyx.com

• Hepatocellular carcinoma (HCC) — for patients previously treated with sorafenib. cabometyx.com

• Medullary thyroid carcinoma (MTC) — for progressive, metastatic disease (this indication uses a higher daily dose historically). FDA Access Data

• Pancreatic and extra-pancreatic neuroendocrine tumours (pNET/epNET) — in selected patients in regions where recently approved. (Check local labelling.) Oncodaily

Cabozanix (cabozantinib) dosing & administration (summary)

• Formulation: Capsules (available in 20 mg, 40 mg, and 60 mg strengths in some brands). Cabozanix by Beacon is supplied as 20 mg capsules; prescribers commonly combine capsule strengths to reach the target total daily dose per indication. Cabozanix

• Common starting doses (examples from international labels — follow local oncology guidance):

  • Medullary thyroid cancer (MTC): historically 140 mg once daily (capsule combinations totaling 140 mg) taken on an empty stomach; continue until disease progression or unacceptable toxicity. FDA Access Data

  • Renal cell carcinoma (RCC): 40–60 mg once daily depending on whether given alone or in combination with immunotherapy (e.g., 40 mg daily with nivolumab in some first-line regimens). European Medicines Agency (EMA)

  • Hepatocellular carcinoma (HCC): typical doses described in labels are 60 mg once daily (check local guidance and adjust for tolerability). FDA Access Data

• Administration advice: take on an empty stomach (no food for at least 2 hours before and 1 hour after dosing) unless otherwise directed; swallow capsules whole. Avoid grapefruit/grapefruit juice. Dose reductions, interruptions, or discontinuation are often required for intolerable toxicities. cabometyx.com

Important: the capsule strength you have (20 mg) is commonly used in combination (multiple capsules) to reach the required daily dose. Always follow the exact regimen and dose modifications prescribed by the treating oncologist.

Cabozantinib Side Effects:

Common adverse reactions (occur frequently and often require supportive care or dose adjustment):

• Diarrhoea, nausea, vomiting, and abdominal pain. Mayo Clinic

• Fatigue and decreased appetite/weight loss. Mayo Clinic

• Palmar-plantar erythrodysesthesia (hand-foot syndrome), stomatitis/mucositis. cabometyx.com

• Hypertension (new or worsening). cabometyx.com

Serious / potentially life-threatening reactions (require immediate attention and often treatment interruption/discontinuation):

• Severe hepatotoxicity (elevated ALT/AST, bilirubin) — can be fatal. Monitor liver tests closely. cabometyx.com

• Hemorrhage (including fatal bleeding), gastrointestinal perforation, and fistula formation. FDA Access Data

• Cardiovascular events — ischemia, myocardial infarction, QT prolongation (monitor as indicated). cabometyx.com

• Wound healing complications — avoid starting or continuing around major surgery without specialist guidance. cabometyx.com

This list is not exhaustive; individual patients may experience other adverse effects. Dose interruptions and reductions are commonly required to manage toxicity. cabometyx.com

Precautions, contraindications & drug interactions

• Baseline assessments: liver function tests, blood pressure, CBC, electrolytes, and cardiac history. Reassess periodically during therapy. cabometyx.com

• Avoid strong CYP3A4 inhibitors/inducers where possible (they can raise or lower cabozantinib exposure). Dose adjustments may be required if co-administration cannot be avoided. Examples: ketoconazole (inhibitor) increases levels; rifampin (inducer) reduces levels. Medscape Reference

• Pregnancy & fertility: cabozantinib is teratogenic in animals — women of childbearing potential must use effective contraception during treatment and for a defined period after stopping (follow label). Men should use contraception as advised. cabometyx.com

• Surgery: interrupt treatment prior to planned major surgery as directed by the surgeon/oncologist because of the risk of impaired wound healing. cabometyx.com

Practical counselling points for patients

• Take the medication exactly as prescribed and do not crush or open capsules. Take on an empty stomach unless otherwise told. Cabozanix

• Report new or worsening shortness of breath, chest pain, severe abdominal pain, severe diarrhoea, significant bleeding, yellowing of eyes/skin, or signs of infection immediately. cabometyx.com

• Monitor and record blood pressure at home if advised. Maintain hydration and report severe diarrhoea early. Mayo Clinic

• Store in the original container, away from children, at room temperature as instructed by the packaging.

Why choose Cabozanix (practical notes for prescribers / pharmacists)

• Local brand availability: Cabozanix (Beacon) supplies cabozantinib in 20 mg capsules which allows flexible dosing by combining capsule strengths. Confirm supply, batch details and local regulatory labelling prior to prescribing. Cabozanix

• Cost context: you are provided the pack price of PKR 212,500 for 90 capsules; actual patient cost will depend on pharmacy markups, insurance/health system coverage, and whether higher strength branded products are available. Consider supportive care costs and monitoring burden when discussing therapy with patients.

Monitoring checklist (practical)

• Baseline and periodic: LFTs (ALT/AST, bilirubin), CBC, electrolytes, renal function. cabometyx.com

• Blood pressure at baseline and frequently while on therapy. cabometyx.com

• Skin checks for hand-foot syndrome; oral exam for mucositis. Mayo Clinic

• Signs of bleeding, GI perforation, and wound healing issues — educate patient and coordinate with surgical teams if relevant. FDA Access Data

Disclaimer

This is an informational product description based on public sources and the price you supplied. It does not replace the official prescribing information, local regulatory labelling, or specialist oncologist judgment.

For prescribing, dose adjustments, drug interactions and management of adverse events follow the treating oncologist and local approved label.