₨ 3,500 Original price was: ₨ 3,500.₨ 3,350Current price is: ₨ 3,350.Uperio is a medication that combines two active ingredients, sacubitril and valsartan, in a single tablet.
It is used in the treatment of heart failure with reduced ejection fraction (HFrEF) in adult patients.
Sacubitril is a neprilysin inhibitor, while valsartan is an angiotensin receptor blocker (ARB).
Together, they work synergistically to provide enhanced therapeutic benefits for heart failure patients.
Sacubitril inhibits the enzyme neprilysin,
which is responsible for breaking down certain hormones involved in regulating blood pressure and fluid balance.
By inhibiting neprilysin, sacubitril increases the levels of these beneficial hormones, leading to vasodilation (widening of blood vessels), reduced sodium and fluid retention, and improved cardiac function.
Valsartan, an ARB, blocks the action of angiotensin II, a hormone that causes blood vessels to constrict.
By inhibiting angiotensin II, valsartan helps relax and widen the blood vessels, reducing blood pressure and relieving strain on the heart.