Zeptide vs. Tirzee — a Practical, Evidence-based Comparison (Efficacy, Safety, Formulation & Cost in Pakistan)
Tirzepatide is one of the most talked-about newer diabetes and weight-loss medicines: a dual GIP/GLP-1 receptor agonist that has shown impressive glucose-lowering and weight-loss effects in clinical trials.
In Pakistan, you can now find locally produced versions under names such as Zeptide (Ferozsons) and Tirzee (Getz Pharma).
Below, I compare them across the variables you asked for: mechanism & efficacy, safety/side effects, formulation & availability, and cost — with evidence and practical takeaways.
1) Quick summary
- Mechanism & efficacy: Both contain tirzepatide, so they share the same mechanism and clinical benefits demonstrated in major trials (strong glucose lowering and substantial weight loss compared with older agents).
- Safety: Class side effects are mainly gastrointestinal (nausea, diarrhea, vomiting); rarer but important concerns include pancreatitis, gallbladder disease, and effects related to rapid glucose lowering. Serious risks and monitoring recommendations are those described in the original tirzepatide product labeling. (FDA Access Data)
- Formulation/device: Zeptide is marketed as a prefilled syringe (PFS); Tirzee is marketed as a prefilled pen/auto-injector similar to other weekly GLP-1 pens. That affects ease of use and dose titration.
- Cost (retail prices you provided): Zeptide is substantially less expensive than Tirzee across comparable strengths — and Zeptide offers additional higher-dose options (12.5 mg, 15 mg). See the detailed price table below.
2) Mechanism & clinical effectiveness (what the trials show)
Tirzepatide is an engineered peptide that activates both GIP and GLP-1 receptors. That dual action improves insulin secretion and satiety/weight loss to a greater degree than many earlier agents.
Large randomized trials showed dose-dependent improvements in HbA1c and substantial body-weight reductions (SURPASS and SURMOUNT program data).
For example, SURMOUNT-1 showed striking weight loss in people with overweight/obesity treated with tirzepatide versus placebo.
Other trials showed tirzepatide reduced HbA1c and outperformed weekly semaglutide in several measures.
Practical implication: since Zeptide and Tirzee contain the same active molecule (tirzepatide), their potential efficacy is expected to be similar, assuming the same dosing and proper storage/administration. Real-world effectiveness can vary with adherence, device use, and product handling.
3) Safety and common side effects
Most adverse reactions are gastrointestinal and dose-related (nausea, diarrhea, decreased appetite, vomiting, constipation).
These are most frequent during dose escalation and often decrease over time. Other warnings reported in tirzepatide clinical data and product labeling include pancreatitis, acute gallbladder disease, acute kidney injury from dehydration (if severe vomiting), hypoglycemia when used with insulin or sulfonylureas, and potential issues in patients with a history of diabetic retinopathy.
Full safety guidance follows the product labeling for Mounjaro/tirzepatide. (FDA Access Data)
Practical advice: start low and escalate per prescribing guidance, report persistent severe GI symptoms, do not combine with other glucose-lowering drugs without clinician oversight, and discuss thyroid cancer family history (some incretin class agents carry murine thyroid tumor signals and have cautionary guidance — follow local label guidance).
(For clinicians: specific adverse-event rates and monitoring details are summarized in the tirzepatide label and major trial publications.) (FDA Access Data)
4) Formulation & usability — pen vs prefilled syringe
- Zeptide (Ferozsons) — marketed locally as a pre-filled syringe (PFS). Prefilled syringes are straightforward but can require a little more hands-on technique (remove cap, inject) compared to a pen that clicks and dials. Local product pages and manufacturer notices list Zeptide as a PFS.
- Tirzee (Getz Pharma) — described and sold as a prefilled pen / autoinjector (one-shot pen devices like Trulicity/other GLP-1 pens). Pens are generally easier for many patients (less visible needle, simpler injection technique, built-in dose mechanism).
Practical implication: if manual injection technique, needle anxiety, or ease of self-administration is important, a pen/autoinjector (Tirzee) may be preferred even if it costs more. Conversely, PFS (Zeptide) may be slightly cheaper but might feel less convenient for some users.
5) Price comparison (your supplied retail numbers + real-world listings)
You gave these retail numbers — I present them unchanged, then note typical retail listings that reflect similar ranges.
User-supplied retail prices
| Strength | Zeptide (Ferozsons) retail | Tirzee (Getz) retail |
|---|---|---|
| 2.5 mg | Rs 2,950 | Rs 4,000 |
| 5 mg | Rs 3,950 | Rs 6,000 |
| 7.5 mg | Rs 4,950 | Rs 7,500 |
| 10 mg | Rs 5,950 | Rs 10,000 |
| 12.5 mg | Rs 6,250 | (not listed) |
| 15 mg | Rs 6,500 | (not listed) |
Market listings confirm the same pattern: local pharmacies and online retailers list Zeptide PFS in the lower price range, and Tirzee pens in the higher bracket — and Tirzee is commonly sold in pen format with retail prices that are materially higher than Zeptide at comparable strengths.
Practical implication: Zeptide is substantially more cost-effective per dose and offers higher dose options (12.5 mg, 15 mg) that Tirzee listings may not show locally. If budget is the main concern, Zeptide provides better value. If the convenience of a pen device is more important, Tirzee may be worth the premium for some patients.
6) Other considerations before choosing
- Cold-chain and storage: Biologic peptides require careful storage (usually refrigerated). Ensure reliable pharmacy storage and check expiration/handling. Improper storage can reduce effectiveness.
- Dosing and titration: Weekly titration schedules are used — follow a clinician’s recommended titration to minimize GI side effects. Pens can make titration simpler for many patients.
- Authentication & batch quality: Buy from reputable pharmacies to avoid counterfeit or mishandled products. Both Ferozsons and Getz are established local manufacturers, but always confirm packaging, expiry, and storage.
- Prescription & monitoring: Tirzepatide should only be used under medical supervision. Baseline labs, periodic monitoring, and clinician follow-up are essential (as per label and your prescriber’s advice).
7) Bottom line/recommendation
- If cost & dose options are the top priorities → Zeptide (Ferozsons) looks like the better value and offers additional higher doses (12.5 mg, 15 mg).
- If ease of use (autoinjector/pen format) and a familiar pen device are more important and cost is less constraining → Tirzee (Getz Pharma) may be preferred.
- Regardless of brand: discuss with your physician about titration, interactions with insulin/sulfonylureas, and baseline screening. Monitor for GI side effects, pancreatitis warning signs, and other label-specified risks.
8) Sources & further reading (key references)
- Getz Pharma product page — Tirzee (product & prescribing/indication info).
- Ferozsons / local listing for Zeptide PFS (product listing showing Zeptide as prefilled syringe).
- Jastreboff et al., SURMOUNT-1 tirzepatide obesity trial (NEJM) — major weight-loss evidence. (New England Journal of Medicine)
- Frías et al., tirzepatide glycemic efficacy vs semaglutide (NEJM phase 2/3 evidence). (New England Journal of Medicine)
- MOUNJARO (tirzepatide) FDA label — adverse events, warnings, and trial safety data (useful for safety/monitoring). (FDA Access Data)
Injection Zeptide (Mounjaro Alternative in Pakistan) | The Cheapest Tirzepatide Available
Zeptide Injections in Pakistan:
Zeptide is Pakistan’s most affordable tirzepatide brand (Mounjaro® alternative), manufactured by Ferozsons.
It is a once-weekly injection used to improve blood sugar control in Type 2 Diabetes and supports significant weight loss when combined with diet and lifestyle changes.
Available in:
- 2.5 mg,
- 5 mg,
- 7.5 mg,
- 10 mg,
- 12.5 mg, and
- 15 mg once weekly injections at affordable prices.
Common side effects include nausea, vomiting, stomach upset, and decreased appetite.
Not for Type 1 diabetes or during pregnancy.
It is a prescription-only medicine.
Tirzee Injection by Getz Pharma | 2.5 mg, 5 mg, 7.5 mg, and 10 mg Pens | for Weight Loss and Diabetes
Tirzee Injection – Mounjaro (Tirzepatide) Alternative in Pakistan | Getz Pharma
Tirzee Injection contains Tirzepatide, a dual GIP and GLP-1 receptor agonist developed by Getz Pharma as a locally manufactured alternative to Mounjaro. It is used for the management of type 2 diabetes and supports effective weight loss when combined with diet and exercise.
Product Details:
- Generic: Tirzepatide
- Brand: Tirzee
- Manufacturer: Getz Pharma
- Available Strengths & Prices:
- 2.5 mg pen – Rs. 4,000
- 5 mg pen – Rs. 6,000
- 7.5 mg pen – Rs. 7,500
- 10 mg pen – Rs. 10,000
- Administration: Once-weekly subcutaneous injection
✅ Helps lower blood sugar levels
✅ Promotes significant and sustained weight loss
✅ Convenient once-weekly dosing
✅ Cost-effective Mounjaro alternative in Pakistan
Use under medical supervision only. Not suitable for individuals with a history of thyroid cancer or pancreatitis.
