Hypertension and Heart Diseases

Brand Name: Arbi

Generic Name: Irbesartan

Dosage Strength: 300mg

Manufacturer: PharmaEvo Pharmaceutical (Pvt) Ltd.

Packing: 10 Tablets

Description and Usage:

Arbi (Irbesartan) 300mg Tablets are indicated for the following conditions:

• Hypertension (high blood pressure): Irbesartan helps to lower blood pressure by blocking the action of angiotensin II, a hormone that narrows blood vessels and increases blood pressure.
• Diabetic nephropathy: Irbesartan may be used to slow the progression of kidney damage in patients with type 2 diabetes and high blood pressure.

Irbesartan is an angiotensin II receptor blocker (ARB) that selectively blocks the binding of angiotensin II to its receptors. By blocking the action of angiotensin II, irbesartan relaxes blood vessels, leading to vasodilation and lowering of blood pressure. It also helps to reduce the workload on the heart and protect the kidneys from damage.

Brand Name: X-Plended EZ

Generic Name: Rosuvastatin + Ezetimibe

Dosage Strength: 20mg Rosuvastatin + 10mg Ezetimibe

Manufacturer: PharmaEvo Pharmaceutical (Pvt) Ltd.

Packing: 10 Tablets

Description and Usage:

X-Plended EZ (Rosuvastatin+Ezetimibe) tablets are indicated for the treatment of hypercholesterolemia and mixed dyslipidemia, including:

• Elevated levels of low-density lipoprotein cholesterol (LDL-C)
• Elevated levels of total cholesterol
• Elevated levels of non-high-density lipoprotein cholesterol (non-HDL-C)
• Elevated levels of triglycerides (in combination with a statin)
• In patients with homozygous familial hypercholesterolemia (in combination with other lipid-lowering treatments)

• Rosuvastatin: Rosuvastatin is a statin medication that works by inhibiting the enzyme HMG-CoA reductase, which is involved in cholesterol synthesis in the liver. By blocking this enzyme, Rosuvastatin reduces the production of cholesterol, leading to decreased levels of LDL-C (“bad” cholesterol) and triglycerides.
• Ezetimibe: Ezetimibe works by inhibiting the absorption of cholesterol in the small intestine, thereby reducing the amount of cholesterol that enters the bloodstream. It primarily inhibits the absorption of dietary cholesterol and cholesterol derived from bile.

Brand Name: X-Plended

Generic Name: Rosuvastatin

Dosage Strength: 10mg

Manufacturer: PharmaEvo Pharmaceutical (Pvt) Ltd.

Packing: 10 Tablets

Description and Usage:

X-Plended (Rosuvastatin) 10mg Tablets are indicated for the treatment of hypercholesterolemia (elevated cholesterol levels) and dyslipidemia (abnormal lipid levels), including:

• Hypercholesterolemia: Elevated levels of total cholesterol and/or low-density lipoprotein cholesterol (LDL-C).
• Mixed dyslipidemia: Elevated levels of LDL-C, triglycerides, and low levels of high-density lipoprotein cholesterol (HDL-C).
• Homozygous familial hypercholesterolemia: An inherited condition causing extremely high levels of LDL-C.

Rosuvastatin belongs to a class of medications known as statins. It works by inhibiting the enzyme HMG-CoA reductase, which plays a key role in cholesterol synthesis in the liver. By blocking this enzyme, Rosuvastatin reduces the production of cholesterol, leading to decreased levels of LDL-C (“bad” cholesterol) and triglycerides, and increased levels of HDL-C (“good” cholesterol).

Brand Name: Avsar Plus

Generic Name: Valsartan, Amlodipine, and Hydrochlorothiazide

Dosage Strength: 160mg Valsartan + 10mg Amlodipine + 12.5mg Hydrochlorothiazide

Manufacturer: PharmaEvo Pharmaceutical (Pvt) Ltd.

Packing: 28 Tablets

Description and Usage:

Avsar Plus is a medication that combines three active ingredients: Valsartan, Amlodipine, and Hydrochlorothiazide. It is available in tablet form with the following composition: 160mg of Valsartan, 10mg of Amlodipine, and 12.5mg of Hydrochlorothiazide per tablet.

• Valsartan (160mg): An angiotensin II receptor blocker (ARB) that helps to relax blood vessels, lowering blood pressure.
• Amlodipine (10mg): A calcium channel blocker (CCB) that relaxes blood vessels, reducing blood pressure and improving blood flow.
• Hydrochlorothiazide (12.5mg): A thiazide diuretic that helps the kidneys remove excess sodium and water from the body, reducing blood volume and lowering blood pressure.

Management of hypertension (high blood pressure) in patients who require treatment with multiple antihypertensive agents to achieve blood pressure control.

Each component of Avsar Plus works differently to lower blood pressure. Valsartan blocks the action of angiotensin II, a hormone that constricts blood vessels. Amlodipine blocks calcium channels in blood vessels, leading to relaxation and vasodilation. Hydrochlorothiazide increases urine production, reducing blood volume and pressure.

Brand Name: Xcept

Generic Name: Rivaroxaban 

Dosage Strength: 20mg

Manufacturer: PharmaEvo Pharmaceutical (Pvt) Ltd.

Packing: 10 Tablets

Description and Usage:

Xcept (Rivaroxaban) 20mg tablets are a medication primarily used for the prevention of blood clots in certain medical conditions. Rivaroxaban is the active ingredient in Xcept, and it belongs to a class of medications known as direct oral anticoagulants (DOACs) or factor Xa inhibitors.

Rivaroxaban works by inhibiting the activity of factor Xa, which is an essential component in the coagulation (blood clotting) cascade. By inhibiting factor Xa, Rivaroxaban prevents the formation of blood clots.

Brand Name: Telsarta

Generic Name: Telmisartan

Dosage Strength: 40mg

Manufacturer: PharmaEvo Pharmaceutical (Pvt) Ltd.

Packing: 10 Tablets

Description and Usage:

Telsarta is a medication brand that typically contains the active ingredient Telmisartan in 40mg tablet form. Telmisartan is an angiotensin II receptor blocker (ARB) used primarily to treat hypertension (high blood pressure). Here’s a description of Telmisartan and its potential effects:

Telmisartan works by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict. By blocking angiotensin II receptors, Telmisartan relaxes blood vessels, lowers blood pressure, and reduces the workload on the heart.

Brand Name: Telsarta-D

Generic Name: Telmisartan and Hydrochlorothiazide

Dosage Strength: 40mg Telmisartan and 12.5mg Hydrochlorothiazide

Manufacturer: PharmaEvo Pharmaceutical (Pvt) Ltd.

Packing: 14 Tablets

Description and Usage:

Telsarta-D is a medication brand that typically contains a combination of two active ingredients: Telmisartan and Hydrochlorothiazide, in a ratio of 40mg of Telmisartan and 12.5mg of Hydrochlorothiazide per tablet. This combination medication is used to treat hypertension (high blood pressure).

The combination of Telmisartan and Hydrochlorothiazide in Telsarta-D tablets provides complementary mechanisms of action for the treatment of hypertension. Telmisartan works by blocking the effects of angiotensin II, while Hydrochlorothiazide promotes diuresis and decreases blood volume. Together, they help to lower blood pressure more effectively than either medication alone.

Brand Name: Sacvin 100

Generic Name: Sacubitril and Valsartan

Dosage Strength: 49mg Sacubitril and 51mg Valsartan

Manufacturer: PharmaEvo Pharmaceutical (Pvt) Ltd.

Packing: 30 Tablets

Description and Usage:

Sacvin 100 is a medication brand that typically contains a combination of two active ingredients: Sacubitril and Valsartan, in a ratio of 49mg of Sacubitril and 51mg of Valsartan per tablet. This combination medication is used to treat heart failure with reduced ejection fraction.

The combination of Sacubitril and Valsartan in Sacvin 100 tablets provides complementary mechanisms of action for the treatment of heart failure with reduced ejection fraction. Sacubitril increases natriuretic peptides to promote vasodilation and diuresis, while Valsartan blocks the effects of angiotensin II to reduce vasoconstriction and sodium retention.