Hernix 40 mg Tablets (Niratinib in Pakistan) for Breast Cancer

Hernix (Niratinib in Pakistan):

Brand Name: Hernix

Generic Name: Niratinib

Strength: 40 mg Tablets

Manufacturer: Beacon Pharmaceutical

Pack Size: 180 Tablets

Price: PKR 525,000 (per pack)

Availability: Prescription Only – Oncology Medication

🔶 Hernix (Niratinib in Pakistan): Overview

Hernix (Niratinib) is an oral, irreversible pan-HER tyrosine kinase inhibitor (TKI) used for the extended adjuvant treatment of certain types of breast cancer. It targets HER2-positive tumors and helps reduce the risk of cancer recurrence after primary therapy.

It works by blocking HER2 and other epidermal growth factor receptors involved in cancer cell growth, thereby slowing or stopping tumor progression.

🔶 Key Indications of Hernix (Niratinib in Pakistan):

Hernix (Niratinib) is prescribed for the following conditions:

1. HER2-Positive Early Breast Cancer

• Used as extended adjuvant therapy after trastuzumab (Herceptin) treatment.

• Helps reduce risk of recurrence in high-risk patients.

2. Metastatic HER2-Positive Breast Cancer

• Used alone or in combination with other agents (e.g., capecitabine).

• Recommended for patients who have received ≥2 prior anti-HER2 therapies.

3. HER2-Mutant Breast Cancer (Off-label)

• May be used in selected cases where activating HER2 mutations are present.

🔶 How Hernix (Niratinib) Works

Niratinib is an irreversible tyrosine kinase inhibitor that targets:

• HER2

• HER4

• Epidermal growth factor receptors (EGFR)

By permanently binding to these receptors, it blocks signaling pathways that promote cancer cell survival, proliferation, and metastasis.

🔶 Dosage & Administration of Niratinib

Standard Adult Dose

• 240 mg orally once daily
  (Usually taken as six 40 mg tablets)

• Duration: 12 months (extended adjuvant therapy)

How to Take

• Take with food, preferably at the same time daily.

• Swallow tablets whole with water.

• Avoid grapefruit and grapefruit juice.

Loperamide Prophylaxis

• First 2 months:
  Loperamide is usually recommended to reduce risk of diarrhea.

Dose Adjustments

Required in case of:

• Severe diarrhea

• Liver impairment

• Persistent vomiting

• Other toxicities

Always follow the oncologist’s instructions.

🔶 Niratinib Side Effects

Niratinib may cause side effects. Some require immediate medical attention.

Common Side Effects

• Diarrhea (most common)

• Nausea or vomiting

• Abdominal pain

• Fatigue

• Decreased appetite

• Rash or skin dryness

• Mouth ulcers

• Muscle cramps

• Indigestion

• Increased liver enzymes

Serious Side Effects

• Severe or persistent diarrhea → dehydration, electrolyte imbalance

• Hepatotoxicity (increased ALT/AST, bilirubin)

• Severe vomiting/abdominal pain

• Interstitial lung disease (rare)

• Cardiac dysfunction (rare)

• Severe hypersensitivity reactions

Warning Signs Requiring Urgent Care

• Dark urine

• Yellowing of skin/eyes

• Severe dehydration

• Chest pain or shortness of breath

• Severe rash

• Confusion or weakness

🔶 Contraindications of Hernix (Niratinib)

Hernix should NOT be used in:

• Pregnant women (may cause fetal harm)

• Breastfeeding mothers

• Patients with known hypersensitivity to Niratinib or excipients

• Severe hepatic impairment (use with caution)

🔶 Precautions & Monitoring

• Regular liver function tests are required

• Monitor hydration status

• Effective contraception is recommended during treatment

• Avoid strong CYP3A4 inhibitors/inducers

• Patients must report severe diarrhea immediately

🔶 Storage Information

• Store below 25°C

• Protect from light and moisture

• Keep out of reach of children

🔶 Disclaimer

This product description is for informational purposes only. Hernix (Niratinib) is a high-potency prescription oncology medication that must be used strictly under the supervision of a qualified oncologist. Do not start, stop, or alter the dose without medical advice. Side effects, dosage, and treatment duration vary by patient. Gileaz Online Pharmacy does not replace professional medical consultation.