Afanix Tablet (Afatinib 40 mg) – Price and Availability in Pakistan

Description

Afanix Tablet contains Afatinib 40 mg, a highly effective tyrosine kinase inhibitor (TKI) used in the treatment of specific types of lung cancer.

Manufactured by Beacon Pharmaceutical, this medication is designed to target and block abnormal proteins that drive cancer growth, offering improved disease control and prolonged survival in eligible patients.

What is Afatinib (Afanix) Used For?

Afatinib is primarily indicated for:

1. Non–Small Cell Lung Cancer (NSCLC)

• Specifically for EGFR mutation-positive metastatic NSCLC

• Effective in:

  • Exon 19 deletions

  • Exon 21 (L858R) substitution mutations

• Often prescribed as first-line therapy due to its ability to significantly delay disease progression.

2. Squamous Cell Carcinoma of the Lung

• Used in patients whose disease has progressed after platinum-based chemotherapy.

3. HER2-Positive Tumors (Off-label)

• Sometimes used for cancers with HER2 gene mutations, as Afatinib also inhibits HER2 signaling pathways.

Mechanism of Action of Afatinib:

Afatinib works by irreversibly blocking EGFR family receptors, inhibiting tumor cell proliferation and survival. Its broad inhibition (EGFR, HER2, and HER4) makes it effective in resistant or advanced lung cancers.

Benefits of Afanix Tablet

• Targets cancer at the molecular level

• Improves progression-free survival (PFS)

• Useful in patients resistant to first-generation EGFR inhibitors

• Oral, once-daily dosing for convenience

• Effective even in some cases of brain metastasis

Important Information

• Should be prescribed and monitored by an oncologist or cancer specialist

• Common side effects: diarrhea, rash, paronychia, mucositis

• Avoid use in pregnancy and breastfeeding

• Regular liver, kidney, and cardiac monitoring is recommended

Afanix Pricing Details:

• Generic Name: Afatinib

• Brand Name: Afanix

• Strength: 40 mg

• Manufacturer: Beacon Pharmaceutical

• Pack Size: 3 × 10 tablets

• Price: PKR 44,487

• Drug Class: EGFR Tyrosine Kinase Inhibitor (TKI)

• Route: Oral

• Indications: EGFR-mutant NSCLC, Squamous NSCLC post-chemotherapy

Disclaimer

This product description is for educational and informational purposes only. Afatinib is a high-potency anticancer medication and must be used strictly under the supervision of a qualified oncologist. Do not self-medicate or alter the dose without medical advice. Prices may vary by pharmacy.